Expression of M2-macrophages, mTOR-positive cells and VEGF within fibroepithelial skin tags in patients with type 2 metabolic syndrome

April 30, 2020

Aim — to study the expression of M2-macrophages, mTOR-positive cells and vascular endothelial growth factor (VEGF) within fibroepithelial skin tags in patients with type 2 diabetes and metabolic syndrome (MS). Materials and methods. We compared the expression of M2-macrophages, mTOR-positive cells and VEGF within fibroepithelial tags in three groups, depending on the presence and severity of metabolic disorders. Group 1 consisted of patients without metabolic disorders, group 2 — with verified MS, group 3 included patients with type 2 diabetes. Results. Formation of fibroepithelial skin tags in patients with type 2 diabetes and MS is associated with marked M2-macrophage activation against increased expression of the mTOR serine/threonine protein kinase and VEGF at the local level.


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