Expression of M2-macrophages, mTOR-positive cells and VEGF within fibroepithelial skin tags in patients with type 2 metabolic syndrome

April 30, 2020
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Resume

Aim — to study the expression of M2-macrophages, mTOR-positive cells and vascular endothelial growth factor (VEGF) within fibroepithelial skin tags in patients with type 2 diabetes and metabolic syndrome (MS). Materials and methods. We compared the expression of M2-macrophages, mTOR-positive cells and VEGF within fibroepithelial tags in three groups, depending on the presence and severity of metabolic disorders. Group 1 consisted of patients without metabolic disorders, group 2 — with verified MS, group 3 included patients with type 2 diabetes. Results. Formation of fibroepithelial skin tags in patients with type 2 diabetes and MS is associated with marked M2-macrophage activation against increased expression of the mTOR serine/threonine protein kinase and VEGF at the local level.

References:

  • Goryachkina M.V., Belousova T.A. (2014) Dermatologiya. Dobrokachestvennyie epitelialnyie opuholi kozhi. Consilium Medicum, 4: 20–23.
  • Molochkov V., Hlebnikova A. (2006) Dobrokachestvennyie epitelialnyie opuholi kozhi: klinicheskaya kartina, lechenie. Vrach, 2: 39–41.
  • Ackerman J.E., Geary M.B., Orner C.A. et al. (2017) Obesity/Type II diabetes alters macrophage polarization resulting in a fibrotic tendon healing response. PLoS One, 12(7): e0181127. doi: 10.1371/journal.pone.0181127.
  • Appari M., Channon K.M., McNeill E. (2018) Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes. Antioxid. Redox Signal., 29(3): 297–312. doi: 10.1089/ars.2017.7060.
  • Burhans M.S., Hagman D.K., Kuzma J.N. et al. (2018) Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus. Compr. Physiol., 9(1): 1–58. doi: 10.1002/cphy.c170040.
  • Cornu M., Albert V., Hall M.N. (2013) mTOR in aging, metabolism, and cancer. Curr. Opin. Genet. Dev., 23(1): 53–62. doi: 10.1016/j.gde.2012.12.005.
  • Mao Z., Zhang W. (2018) Role of mTOR in Glucose and Lipid Metabolism. Int. J. Mol. Sci., 19(7): E2043. doi: 10.3390/ijms19072043.
  • Morris D.L. (2015) Minireview: Emerging Concepts in Islet Macrophage Bio­logy in Type 2 Diabetes. Mol. Endocrinol., 29(7): 946–962. doi: 10.1210/me.2014-1393.
  • Parisi L., Gini E., Baci D. et al. (2018) Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders? J. Immunol. Res., 2018: 8917804. doi: 10.1155/2018/8917804.
  • Samidurai A., Kukreja R.C., Das A. (2018) Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases. Oxid. Med. Cell Longev., 2018: 6141902. doi: 10.1155/2018/6141902.
  • Shi G.J., Shi G.R., Zhou J.Y. et al. (2018) Involvement of growth factors in diabetes mellitus and its complications: a general review. Biomed. Pharmacother., 101: 510–527. doi: 10.1016/j.biopha.2018.02.105.
  • Thomas D., Apovian C. (2017) Macrophage functions in lean and obese adipose tissue. Metabolism, 72: 120–143. doi: 10.1016/j.metabol.2017.04.005.
  • Tripathy T., Singh B.S.T.P., Kar B.R. (2019) Association of Skin Tag with Metabolic Syndrome and its Components: A Case-control Study from Eastern India. Indian Dermatol. Online J., 10(3): 284–287. doi: 10.4103/idoj.IDOJ_238_18.
  • Vergès B. (2018) mTOR and Cardiovascular Diseases: Diabetes Mellitus. Transplantation, 102 (2S Suppl. 1): S47–S49. doi: 10.1097/TP.0000000000001722.