Morphological manifestation of gylcogen synthesis in the uterus as one of the target markers of reproductive success

April 24, 2020
667
Resume

The problem of reproductive ability of the Ukraine population from year to year does not lose its relevance and is one of the leading causes of the demographic crisis. According to the statistic data the incidence of female infertility continues to be slightly higher than the male one. Pathological changes in the endometrium with infertility are 88%, and in the case of unsuccessful attempts in vitro fertilization is 77.5%. Fertile endometrium is one of the most important factors for successful implantation and keeps of pregnancy, in particular during embryo transfer to the uterus which has been obtained by fertilization in vitro. The study of endometrial morphological markers which are in relevance according to fertility can significantly reduce reproductive losses, improve in vitro fertilization results, and optimize algorithms for managing patients with infertility.

Published: 24.04.2020

References:

  • Veropotvelyan P.N., Tsehmistrenko I.S. (2017) Klinicheskiy vzglyad na problemu neeffektivnosti popyitok EKO pri retseptivnosti endometriya. endokrinol., 33: 32–39.
  • Voronina L.M., Desenko L.M., Madiievska N.M. ta in. (2000) Biolohichna khimiia. Osnova, Kharkiv, 274–281.
  • Harashchenko T.M. (2011) Reproduktyvni vtraty vnaslidok mertvonarodzhen v Ukraini: demohrafichnyi aspekt. Demohrafiia ta sotsialna ekonomika, 2(16): 156–165. DOI: https://doi.org/10.15407/dse2011.02.156.
  • Dumanska V.P. (2018) Vnesok novitnikh reproduktyvnykh tekhnolohii u narodzhuvannist v Ukraini. Demography and Social Economy, 2(33): 82–93. DOI: https://doi.org/10.15407/dse2018.02.82.
  • Zaporozhan V.M., Tsehelskyi M.R. (2002) Hinekolohichna patolohiia. Atlas. Rozdil 4.
  • Kaminskyi V.V., Yuzko O.M., Dakhno F.V. ta in. (2011) Navchalnyi posibnyk. Dopomizhni reproduktyvni tekhnolohii likuvannia bezpliddia. Ministerstvo okhorony zdorovia Ukrainy, Ministerstvo osvity i nauky Ukrainy. Ukrainskyi derzhavnyi instytut reproduktolohii Natsionalnoi medychnoi akademii pisliadyplomnoi osvity imeni P.L. Shupyka. Kyiv, Ukraina, 11: 327.
  • Kondrikov N.I., Barinova I.V. (2019) Rukovodstvo dlya vrachey. Patologiya matki. Prakticheskaya meditsina, Moskva, 352 s.
  • Kryilova Yu.S., Kvetnoy I.M., Aylamazyan E.K. (2013) Retseptivnost endometriya: molekulyarnyie mehanizmyi regulyatsii implantatsii. Zhurn. akush. zhen. bol., 2: 63–74.
  • Литвин Н.В., Геник Н.І. (2017) Оцінка причин ранніх втрат вагітності у жінок із безпліддям, включених у програму допоміжних репродуктивних технологій. Акуш. гінекол., 1: 84–89. DOI: 10.11603/24116–4944.2017.1.7371.
  • Mihaylov V.M. (1998) Dissertatsiya na soiskanie uchenoy stepeni doktora biologicheskih nauk «Zhiznennyiy tsikl detsidualnyih kletok». Sankt-Peterburg. Ch. 1.1, 1.6, 1.7, 3.2.
  • Мішина К.М., Сердюк Г.П., Дрозд О.О. (2014) Мінімізація абортів як шлях до покращення демографічної ситуації в Україні. Мед. форум, 3(3): 147–151.
  • МОЗ України (2013) Наказ МОЗ України від 09.09.2013 р. № 787 «Про затвердження порядку застосування допоміжних репродуктивних технологій в Україні».
  • Petrov Yu.A. (2016) O mehanizme protivozachatochnogo deystviya vnutrimatochnyih sredstv. Mezhdunar. zhurn. prikl. fundament. issled., 8(5): 724–726.
  • Семенюк Л.М. (2016) Невиношування вагітності у жінок з різними формами гіперандрогенії. Автореф. дис. … докт. мед. наук, Київ, 35 c.
  • Topchieva O.I., Pryanishnikov V.A., Zhemkova Z.P. (1978) Biopsii endometriya. Moskva, Meditsina, 232 s.
  • Trokhymovych O.V., Brazhuk M.V., Chubei H.V. (2014) Patomorfolohichnyi analiz endometriia. Akush. hinekol. reproduktol., 23(3): 227–232.
  • Tsentr medychnoi statystyky MOZ Ukrainy (2019) Informatsiino-statystychnyi dovidnyk pro dopomizhni reproduktyvni tekhnolohii Ukrainy.
  • Shcherbyna M.O., Tkachova O.V., Skorbach O.I. (2015) Pidhotovka endometriiu do implantatsii v zhinok reproduktyvnoho viku. Neonatol. khir. perynat. med., 3(17): 89–93.
  • Yarotskyi M.Ie., Semeniuk L.M. (2016) Do pytannia optymizatsii vidnovlennia retseptornoho potentsialu endometriia patsiientok iz syndromom polikistoznykh yaiechnykiv ta zvychnym nevynoshuvanniam vahitnosti v anamnezi. Zdorove zhenshchynы, 1(107): 162–166.
  • Bazer F.W., Wu G., Johnson G.A. et al. (2011) Uterine histotroph and conceptus development: Select nutrients and secreted phosphoprotein 1 affect mechanistic target of rapamycin cell signaling in ewes. Reproduct., 85(6): 1094–1107. DOI:10.1095/biolreprod.111.094722.
  • Bitman J., Cecil H.C., Mench M.L., Wrenn T.R. (1965) Kinetics of in vivo glycogen synthesis in the estrogen-stimulated rat uterus. Endocrinology, 76: 63–69. DOI: 10.1210/endo-76–1-63.
  • Bowman K., Rose J. (2017) Estradiol stimulates glycogen synthesis whereas progesterone promotes glycogen catabolism in the uterus of the American mink (Neovison vison). Sci. J., 88(1): 45–54. DOI: 10.1111/asj.12564.
  • Cornillie F.J., Lauweryns J.M., Brosens I.A. (1985) Normal human endometrium. An ultrastructural survey. Gynecol. Obstet. Invest., 20(3): 113–129. DOI: 10.1159/000298983.
  • Dean M., Hunt J., McDougall L., Rose J. (2014) Uterine glycogen metabolism in mink during estrus, embryonic diapause and pregnancy. Reprod. Dev., 60(6): 438–446. DOI: 10.1262/jrd.2014–013.
  • Demers L.M., Jacobs R.D., Greep R.O. (1973a) Comparative effects of ovarian steroids on glycogen metabolism of rat, rabbit and guinea pig uterine tissue. Soc. Exp. Biol. Med., 143(4): 1158–63. DOI: 10.3181/00379727–143–3749.
  • Demers L.M., Macdonald G.J., Greep R.O. (1973b) Hormonal control of endometrial glycogen metabolism in the Macaca arctoides. J. Phys. Anthropol., 38(2): 183–187. DOI: 10.1002/ajpa.1330380207.
  • Demers L.M., Yoshinaga K., Greep R.O. (1972) Uterine glycogen metabolism of the rat in early pregnancy. Biol. Reprod., 7(2): 297–304. DOI: 10.1093/biolreprod/7.2.297.
  • Ferraretti A.P., Goossens V., Kupka M. (2013) Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE. Hum. Reprod., 28(9): 2318–2331. DOI:10.1093/humrep/det278.
  • Girish C.J., Kotur N.S., Nagarajappa A.H., Manjunath M.L. (2012) A correlative study of endometrial glycogen content and other contributory factors on female infertility. Int. J. Biomed. Adv. Res., 3: 30–35.
  • Gray W., Kocjan G. (2010) Diagnostic Cytothology. Elsevier, 954 p.
  • Heller S., Damm P., Mersebach H. et al. (2010) Hypoglycemia in type 1 diabetic pregnancy role of preconception insulin aspart treatment in a randomized study. Diabetes Care, 33(3): 473–477. DOI:10.2337/dc09–1605.
  • Hughes E.C., Demers L.M., Csermely T., Jones D.B. (1969) Organ culture of human endometrium. Effect of ovarian steroids. Am. J. Obstet. Gynecol., 105(5): 707–720. DOI: 10.1016/0002–9378(69)90007–6.
  • Hughes E.C., Jacobs R.D., Rubulis A., Husney R.M. (1963) Carbohydrate pathways of the endometrium. Effects on ovular growth. Am. J. Obstet. Gynecol., 85: 594–609. DOI: 10.1016/0002–9378(63)90306–5.
  • Maeyama M., Sudo I., Saito K. et al. (1977) Glycogen estimation by a rapid enzymic method in very small samples of human endometrium: glycogen content in the endometrium of infertile patients during the menstrual cycle. Fertil. Steril., 28(2): 159–162. DOI: 10.1016/s0015–0282(16)42375–7.
  • Paul P.K., Duttagupta P.N. (1973) Inhibition of oestrogen-induced increase in hepatic and uterine glycogen by progesterone in the rat. Acta Endocrinol. (Copenh), 72(4): 762–770. DOI: 10.1530/acta.0.0720762.
  • Rose J., Hunt J., Shelton J. et al. (2011) The effects of estradiol and catecholestrogens on uterine glycogen metabolism in mink (Neovison vison). Theriogenology, 75(5): 857–866. DOI: 10.1016/j.theriogenology.2010.10.028.
  • Rubulis A., Jacobs R.D., Hughes E.C. (1965) Glycogen synthetase in mammalian uterus. Biophys. Acta, 99(3): 584–586. DOI: 10.1016/s0926–6593(65)80222–3.
  • Spornitz U.M. (1992) The functional morphology of the human endometrium and decidua. Adv. Anat. Embryol. Cell Biol., 124: 1–99. DOI: 10.1007/978–3-642–58099–4.
  • United Nations (2017) World Population Prospects. The 2017 Revision (https://www.un.org/development/desa/publications/world-population-prospects-the-2017-revision.html).
  • Verma V. (1983) Ultrastructural changes in human endometrium at different phases of the menstrual cycle and their functional significance. Gynecol. Obstet. Invest., 15(4): 93–212. DOI: 10.1159/000299412.
  • Yanez A.J., Nualart F., Droppelmann C., Bertinat R. (2003) Broad expression of fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase provide evidence for gluconeogenesis in human tissues other than liver and kidney. J. Cell. Physiol., 197(2): 189–97. DOI: 10.1002/jcp.10337.
  • Zawar M.P., Deshpande N.M., Gadgil P.A., Mahanta A.A. (2003) Histopathological study of endometrium in infertility. Ind. J. Pathol. Microbiol., 46(4): 630–633.
  • Zimmer D.B., Magnuson M.A. (1990) Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues. Histochem. Cytochem., 38(2): 171–178. DOI: 10.1177/38.2.1688895.