Influence of neoadjuvant targeted therapy on renal functional in patients with localized renal cell carcinoma

January 30, 2020
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Objective — to determine the impact of neoadjuvant targeted therapy (NTT) on renal function in patients with localized renal cell carcinoma (RCC). Маterials and methods. 75 patients with localized RCC, who underwent two cycles of NTT in the period from 2017 to 2019, determining with serum creatinine, total glomerular filtration rate (GFR) by CKD-EPI and MDRD formulars and GFR on the RCC side according to dynamical renoscintigraphy. Results. Serum creatinine before and after NTT was 90.4±22.4 and 90.6±18.3 μmol/l, respectively (p=0.95). Statistically significant difference in the level of total GFR by the selected formulas was not found (p=0.8 and p=0.7, respectively). No differences between indices of separation GFR on the side of RCC lesion before and after NTT were found (46.5±12.9 and 47.4±15.6 ml/min, respectively; p=0.84). Conclusions. Carrying out two blocks of NTT to patients with localized RCC does not lead to a statistically significant decrease in serum creatinine (p=0.95), does not affect the level as total GFR (p=0.7) and GFR on the tumor side (p=0.84), and may be considered safe.

Published: 30.01.2020

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