Severity prediction of acute alimentary pancreatitis based on laboratory parameters

September 26, 2019
Specialities :

Aim — to evaluate changes of laboratory parameters in patients with alimentary acute pancreatitis (AP) based on repeated measurements and to determine their role in severity prediction. Object and research methods. Seventy patients with alimentary AP were examined (average age of 45.4±13.87 years). Severe pancreatitis was found in 34 (48.57%), moderate — in 25 (35.72%), mild — in 11 (15.71%) people. The severity of the AP was assessed using the Atlanta classification (2012). To predict the severity of AP repeated measurements of the levels of rod neutrophils, amylase, and glucose were performed. Results. Significantly higher chances of mild course of AP were found in patients with values of rod neutrophils <7%, amylase <64 units and glucose <3.3 mmol/l established in the initial measurement and during treatment. Proved medium-term prognostic criteria are glucose values of 3.3–5.5 mmol/l in the initial measurement and during treatment. In patients with rod neutrophil values ≥7%, amylase>64 units and glucose ≥5.5 mmol/l at the initial measurement and during treatment proved significantly higher chances of forming a severe disease course. Difficulty criteria are also increased levels of rod neutrophils and glucose established after treatment completion. Conclusions. High informativeness of laboratory parameters in the severity prediction of AP and their significant difference in the studied groups have been proved.

Published: 26.09.2019

  • Goncharov M.P., Shveda Yu.I. (2016) AnalItichna otsInka hIrurgIchnogo lIkuvannya gostrogo pankreatitu. VIsn. probl. bIol. med., 1(126): 151–156.
  • Cho J.H., Kim T.N., Chung H.H., Kim K.H. (2015) Comparison of scoring systems in predicting the severity of acute pancreatitis. World J. Gastroenterol., 21(8): 2387–2394.
  • Greenberg J.A., Hsu J., Bawazeer M. et al. (2016) Clinical practice guideline: management of acute pancreatitis. Can. J. Surg., 59(2): 128–140.
  • Karakayali F.Y. (2014) Surgical and interventional management of complications caused by acute pancreatitis. World J. Gastroenterol., 20(37): 13412–13423.
  • Manohar M., Verma A.K., Venkateshaiah S.U. et al. (2017) Pathogenic mechanisms of pancreatitis. World J. Gastrointest. Pharmacol. Therapeut., 8(1): 10–25.
  • Petrov M.S., Yadav D. (2019) Global epidemiology and holistic prevention of pancreatitis. Nat. Rev. Gastroenterol. Hepatol., 16(3): 175–184.
  • Rompianesi G., Hann A., Komolafe O. et al. (2017) Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. The Cochrane database of systematic reviews, 4(4): CD012010.
  • Shah A.P., Mourad M.M., Bramhall S.R. (2018) Acute pancreatitis: current perspectives on diagnosis and management. J. Inflam. Res., 11: 77–85.
  • Staubli S.M., Oertli D., Nebiker C.A. (2015) Laboratory markers predicting severity of acute pancreatitis. Crit. Rev. Clin. Lab. Sci., 52(6): 273–283.
  • van Dijk S.M., Hallensleben N.D.L., van Santvoort H.C. et al.; Dutch Pancreatitis Study Group (2017) Acute pancreatitis: recent advances through randomised trials. Gut., 66(11): 2024–2032.