Development of blood circulation diseases, diabetes mellitus and obesity in emergency workers during 30 years after the accident at ChNPP

July 1, 2019
612
Resume

The development of hypertensive heart disease (HHD), coronary heart disease (CHD), diabetes mellitus (DM) type 2 and obesity in emergency workers (EW) was studied in dynamics during the 30-year after the accident at the ChNPP. It was revealed that after emergency works HHD, CHD, DM type 2 and obesity in the EW developed earlier and at younger age comparing with non-irradiated persons. The majority of EW came down with HHD during the first 10 years, but non-irradiated persons during the 2nd and 3rd decades after the accident. In all EW CHD was detected during the first 20 years after exposure, but in non-irradiated persons during the 3rd decade of the observation period. In 93.9% of EW the development of HHD significantly outpaced the clinical debut of DM on 25.7 years, and 66.7% of EW development CHD on 19.4 years. In 92.0% of non-exposed patients this difference was 19.5, 76.0% and 15.5 years, respectively. HHD significantly increased the risk of developing DM type 2, both in EW and the non-irradiated control. CHD did not show such effect. More than a half of EW and non-irradiated control had excessive body mass or obesity when HHD and CHD developed. Participation in EW under the exposure of ioni­zing radiation may be considered as probable risk factor for HHD, CHD and DM type 2.

Published: 26.06.2019
References:

  • Ametov A.S., Lyisenko M.A. (2011) Saharnyiy diabet 2-go tipa i serdechno-sosudistyie zabolevaniya kak stolknovenie dvuh globalnyih neinfektsionnyih epidemiy. Mezhdunar. endokrinol. zhurn., 7: 56–59.
  • Byuyul A., Tsefel P. (2005) SPSS: iskusstvo obrabotki informatsii. Analiz statisticheskih dannyih i vosstanovlenie skryityih zakonomernostey. «DiaSoft», Moskva, Sankt-Peterburg, Kiev, 603.
  • Galyavi R.A., Mihoparova O.Yu., Oschepkova O.B., Frolova E.B. (2014) Arterialnaya gipertenziya i saharnyiy diabet. Vest. sovr. klin. med., 7(1): 78–81.
  • Dementev V.E., Bitsadze R.M., Obrezan A.G., Kryisyuk O.B. (2010) Aktualnyie voprosyi kardiologicheskoy patologii u bolnyih saharnyim diabetom 2.
  • Dreval A.V. (2018) Menopauza (lektsiya). RMZh, 1: 3–7.
  • Katashkova G.D., Bonitenko Yu.Yu., Nikiforov A.M. i dr. (2002) Somaticheskaya patologiya u likvidatorov posledstviy avarii na Chernobyilskoy AES. Zabolevaniya serdechno-sosudistoy sistemyi. Patologiya otdalennogo perioda u likvidatorov posledstviy avarii na Chernobyilskoy AES. Binom, Moskva, 165–185.
  • Kvasha E.A. (2005) Rasprostranennost izbyitochnoy massyi tela i pokazateli smertnosti u muzhchin v vozraste 40–59 let, prozhivayuschih v g. Kieve (po dannyim prospektivnogo issledovaniya). Ukr. kardiol. zhurn., 6: 109–111.
  • Kovalenko V.M., Lutai M.I., Sirenko Yu.M., Sychov O.S. (2016) Sertsevo-sudynni zakhvoriuvannia. Klasyfikatsiia, standarty diahnostyky ta likuvannia. MORION, Kyiv, 192 s.
  • Lupanov V.P. (2013) Ishemicheskaya bolezn serdtsa i saharnyiy diabet: voprosyi diagnostiki, medikamentoznogo i hirurgicheskogo lecheniya, prognoz (obzor). Med. sovet, 3: 52–61.
  • Meshkov N.A. (2016) Kliniko-epidemiologicheskaya otsenka vliyaniya faktorov riska na razvitie bolezney sistemyi krovoobrascheniya u likvidatorov posledstviy Chernobyilskoy katastrofyi. Radiats. risk, 25(1): 94–107.
  • Mitkovskaya N.P. (2016) Kardiologiya i komorbidnost. I mezhdunarodnyiy kongress kardiologov i terapevtov. Kapital Print, Minsk, s. 173–177.
  • Obrezan A.G. (2008) Struktura serdechno-sosudistyih zabolevaniy u bolnyih saharnyim diabetom 2 tipa, diabeticheskaya kardiomiopatiya kak osoboe sostoyanie miokarda. Vest. SPbGU, 11(2): 47–53.
  • Porovskiy Ya.V. (2015) Komorbidnost vo vrachebnoy praktike. Sib. med. obozr., 4: 5–10.
  • Starchenko T.H., Koval S.M., Yushko K.O. ta in. (2018) Formuvannia porushennia rytmu sertsia u khvorykh na arterialnu hipertenziiu z tsukrovym diabetom 2 typu. Visn. probl. biol. med., 3: 42–46.
  • Telkova I.L. (2010) Osobennosti patologii serdechno-sosudistoy sis­temyi u likvidatorov posledstviy avarii na Chernobyilskoy AES po dannyim kardiologicheskogo statsionara. Byul. sib. med., 5: 180–186.
  • Chesnikova A.I., Batyushin M.M., Terentev V.P. (2016) Arterialnaya gipertenziya i komorbidnost: sovremennoe sostoyanie problemyi. Art. gipert., 22(5): 432–440.
  • Adams K.F., Schatzkin A., Harris T.B. et al. (2006) Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N. Engl. J. Med., 355(8): 763–778.
  • Fihn S.D., Gardin J.M., Abrams J. et al.; American College of Cardiology Foundation; American Heart Association Task Force on Practice Guidelines; American College of Physicians et al. (2012) 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J. Am. Coll. Cardiol., 60(24): e44–e164.
  • Montalescot G., Sechtem U., Achenbach S. et al. (2013) 2013 ESC guidelines on the management of stable coronary artery disease: the task force on the management of stable coronary artery disease of the European Society of Cardiology. Eur. Heart J., 34: 2949–3003.
  • Wilkins E., Wilson L., Wickramasinghe K. et al. (2017) European cardiovascular disease statistics 2017. European Heart Network, Brussels, 192 p.