Thromboprophylaxis in obesity: an overview of current recommendations

May 29, 2019
914
Resume

General disregulation of metabolic homeostasis (metabolic syndrome), which accompanies obesity, leads to insulin resistance, atherogenic dislipoproteinemia and arterial hypertension, which contribute to the development of venous thromboembolism. Obesity increases the risk of thromboembolic complications after surgical interventions by 2–5 times, which requires special approaches to thromboprophylaxis. Modern worldwide guidelines suggest multimodality of thromboprophylaxis with early activation of the patient and a combination of mechanical and pharmacological agents. Low molecular weight heparins are preferable, and their dose is increased according to the body mass index and risk degree. It is recommended that in patients with obesity and high risk of venous thromboembolism pharmacological prophylaxis continue to 10–15 days after hospital discharge.

DOI 10.32471/umj.1680-3051.131.157638

Published: 29.05.2019

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