Current state of chemotherapy and prevention of influenza and ARVI in Ukraine

February 21, 2018
1050
Specialities :
Resume

At present, several approved medicinal drugs for the treatment of influenza are available. Nevertheless, their efficacy is limited by the emergence of drug-resistant forms of viruses and some contraindications. Moreover, other respiratory viral infections are diagnosed in the setting of flu epidemics. While such infections are similar to influenza by their symptom, antiflu agents fail to control them. Besides synthetic neuraminidase inhibitors, a wide range of the natural substances belonging to flavonoids, also possess the activity as neuraminidase inhibition. The prospects for the application of flavonoids as antiviral agents are reviewed. The multi-target mechanism of flavonoid effects is of high importance. The literature data and the results of our own studies of the domestic flavonoid-containing drugs Proteflazid® and Immunoflazid® suggest that they may be recommended as etiotropic and pathogenetic remedy for preventing and treating influenza and other acute respiratory viral infection.

S.L. Rybalko, D.B. Starosyla, M.P. Zavelevich

Key words: influenza, neuraminidase inhibitors, flavonoids, Proteflazid®, Immunoflazid®.

Published: 06.03.2018

References:

  • Abaturov A.E., Vyisochina I.L. (2016) Realizatsiya protivovirusnogo i antioksidantnogo deystviya bioflavonoidov pri lechenii ostryih respiratornyih virusnyih infektsiy. Zdorove rebenka, 5(73): 42–48.
  • Atamanyuk V.P., Novik A.M. (2015) VinahId «BIologIchno-aktivna rechovina polIfarmakologIchnoYi dIYi roslinnogo pohodzhennya» (# a 2015 03915).
  • Beketova G.V., Haytovich N.V., Grinevich A.I. (2014) Immunoflazid v pediatrii: sistemnyiy analiz effektivnosti i bezopasnosti primeneniya. Vostochnaya Evropa, 3(7): 141–152.
  • Kramarev S.A., Grinevich A.I., Tonkovid O.B., Vyigovskaya O.V. (2014) Metaanaliz rezultatov klinicheskih issledovaniy effektivnosti flavonoidov pri virusnyih i virusno-bakterialnyih zabolevaniyah u detey. Sovr. pediatr., 5(61): 1–7.
  • Kuznetsova L.V. (2017) Vliyanie flavonoidov na pokazateli kletochnogo immuniteta u detey i podrostkov, kotoryie boleyut grippom i ostryimi respiratornyimi virusnyimi infektsiyami, do i posle lecheniya. Laboratornaya diagnostika. Vostochnaya Evropa, 6(3): 429–436.
  • Mukvich O.M., Kaminska T.M. (2017) Preventyvna ta likuvalna efektyvnist bioflavonoidiv u ditei z rekurentnymy respiratornymy infektsiiamy. Zdorovia dytyny, 12(2): 124–129.
  • Palchykovska L.H., Vasylchenko O.V., Platonov M.O. ta in. (2013) Antyvirusni vlastyvosti roslynnykh flavonoidiv — inhibitoriv syntezu DNK i RNK. Biopolymers Cell, 29(2): 150–156.
  • Tokarchuk N.I., Starynets L.S. (2012) Vykorystannia Imunoflazidu dlia profilaktyky ta likuvannia hrypu i HRVI u ditei pid chas sezonnoho pidvyshchennia zakhvoriuvanosti. Sovr. pedyatr., 1(41): 123–127.
  • Edmond J.D., Johnston R.G., Kidd D. et al. (1966) The inhibition of neuraminidase and antiviral action. Br. J. Pharmacol. Chemother., 27(2): 415–426.
  • Grienke U., Schmidtke M., Kirchmair J. et al. (2010) Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J. Med. Chem., 53(2): 778–786.
  • Grienke U., Schmidtke M., von Grafenstein S. et al. (2012) Influenza neuraminidase: a druggable target for natural products. Nat. Prod. Rep., 29(1): 11–36.
  • Gubareva L.V., Besselaar T.G., Daniels R.S. et al. (2017) Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2015–2016. Antiviral Res., 146: 12–20.
  • Ha T.K., Dao T.T., Nguyen N.H. et al. (2016) Antiviral phenolics from the leaves of Cleistocalyx operculatus. Fitoterapia, 110: 135–141.
  • Haidari M., Ali M., Ward Casscells S. 3rd, Madjid M. (2009) Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir. Phytomedicine, 16(12): 1127–1136.
  • Hayden F. (2009) Developing new antiviral agents for influenza treatment: what does the future hold? Clin. Infect. Dis., 48(1): S3–S13.
  • Hopkins A.L. (2008) Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol., 4(11): 682–690.
  • Jeong H.J., Ryu Y.B., Park S.J. et al. (2009) Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg. Med. Chem., 17(19): 6816–6823.
  • Jin J., Chen S., Wang D. et al. (2017) Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs. Biomed. Pharmacother., 97: 385–394.
  • Kai H., Obuchi M., Yoshida H. et al. (2014) In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08). J. Funct. Foods, 8: 214–223.
  • Lee C.H., Kim S.I., Lee K.B. et al. (2003) Neuraminidase inhibitors from Reynoutria elliptica. Arch. Pharm. Res., 26(5): 367–374.
  • Liu A.L., Wang H.D., Lee S.M. et al. (2008) Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorg. Med. Chem., 16(15): 7141–7147.
  • Lu S.J., Chong F.C. (2012) Combining molecular docking and molecular dynamics to predict the binding modes of flavonoid derivatives with the neuraminidase of the 2009 H1N1 influenza A virus. Int. J. Mol. Sci., 13(4): 4496–4507.
  • Meijer A., Lackenby A., Hungnes O. et al.; European Influenza Surveillance Scheme (2009) Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season. Emerg. Infect. Dis., 15(4): 552–560.
  • Mercader A.G., Pomilio A.B. (2010) QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors. Eur. J. Med. Chem., 45(5): 1724–1730.
  • Nagai T., Miyaichi Y., Tomimori T. et al. (1990) Inhibition of influenza virus sialidase and anti-influenza virus activity by plant flavonoids. Chem. Pharm. Bull. (Tokyo), 38(5): 1329–1332.
  • Nguyen T.T.H., Kang H.K., Kim Y.M. et al. (2014) Inhibition effect of flavonoid compounds against neuraminidase expressed in Pichia pastoris. Biotechnol. Bioproc. Engineer., 19: 70–75.
  • Wu W., Li R., Li X. et al. (2015) Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses, 8: