Evaluation of the functional state of the retina in patients with diabetic macular edema by modern research methods and their correlation

March 5, 2018
Specialities :

Aim — to evaluate the functional state of the retina in patients with diabetic macular edema (DME) using modern research methods. Materials and methods. We examined 20 patients, 20 eyes (the average age — 57.6±12.4 years). All patients were diagnosed with DME. Рatients in addition to standard research methods were carried out a multifocal electroretinography (mf-ERG), optical coherence tomography (OCT) and microperimetry. Results. The deformation of the retinal profile was identified on the OCT. The average thickness of the retina was 347±10.6 µm. It was established that the average density of the bioelectric response of the macular area of the retina in patients with macular edema is sharply reduced and amounts to 46.37 nV/deg. The average photosensitivity according to the microperimetry was 14.8 dB. These data indicates a decrease of the functional activity and photosensitivity of the retina. The results of the correlation analysis found a negative correlation (r=–0.442) between the morphological changes in the central zone of the retina according to the OCT and functional data according to the mf-ERG as well as a negative correlation between the data of the OCT and microperimetry (r=–0.587). It was noted a positive correlation (r=0.356) between the photosensitivity according to the microperimetry and functional activity of the retina according to the mf-ERG. Conclusions. It can be considered that in patients with DME there is an increase of the thickness of the retina, accompanied by depression of the amplitudes of mf-ERG and decreased photosensitivity. The regularity between the morphological parameters of the foveal zone, its bioelectric activity and photosensitivity was detected.

M.I. Kerimov, N.A. Shahbazova, U.S. Ismailova, G.Ch. Javadova

Key words: diabetic retinopathy, multifocal electroretinography, optical coherence tomography, microperimetry.

Published: 06.03.2018


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