Multiple sclerosis in children

March 16, 2018

In 2.2–10.0% of cases, multiple sclerosis (MS) debuts before age 18. In addition to genetic factors, the etiopathogenesis of MS in children may be associated with modified immunological response to virus infection, especially Epstein — Barr, decrease in vitamin D levels, menarche, obesity, smoking. A wide range of childhood diseases that can mimic MS significantly complicates diagnostics. The clinical course of pediatric MS, especially in young children, differs from an adult. Atypical features of MS in children include fever, involvement of other organs, progressive course of the disease, noticeable pleocytosis and absence of oligoclonal bands in cerebrospinal fluid, presence of encephalopathy and larger foci on magnetic resonance imaging. In children, presence of oligoclonal bands in cerebrospinal fluid in the first demyelinating event is an important prognostic factor of the development of MS. MS in children almost always presents in the relapsing-remittent form. The inflammatory nature of the process in the onset of the disease in children leads to a good result of treatment and good prognosis.

O.M. Baranenko, I.P. Krynychna, Y.P. Tiahlo,
I.V. Bachuryna, G.V. Maksiuta

Key words: multiple sclerosis in children, magnetic resonance imaging, oligoclonal bands.

Published: 14.03.2018


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